- Product Details
Keywords
- Ceftriaxone sodium factory supplier
- Ceftriaxone sodium powder
- Ceftriaxone sodium
Quick Details
- ProName: Ceftriaxone sodium
- CasNo: 74578-69-1
- Molecular Formula: C18H19N8NaO7S3
- Appearance: White powder
- Application: Ceftriaxone sodium is a β-lactamase–re...
- DeliveryTime: 30days
- PackAge: Barreled, aluminum foil bagged
- Port: NINGBO/SHANGHAI
- ProductionCapacity: 30 Metric Ton/Day
- Purity: 99%
- Transportation: Sea, air, and land transportation
- LimitNum: 1 Kilogram
Superiority
- ProName:99% up GMP DMF Ceftriaxone Sodium 7457...
- CasNo:74578-69-1
- Molecular Formula:C18H18N8Na2O7S3
- Appearance:White or almost white hygroscopic powd...
- Application:API
- DeliveryTime:7 working days
- PackAge:25kg per drum
- Port:shanghai/beijing/hangzhou
- ProductionCapacity:1000 Kilogram/Month
- Purity:99%
- Storage:Normal temperature
- Transportation:normal temperature.
- LimitNum:1 Kilogram
-
Ceftriaxone sodium is a β-lactamase–resistantcephalosporin with an extremely long serum half-life.Once-daily dosing suffices for most indications. Two factorscontribute to the prolonged duration of action ofceftriaxone: high protein binding in the plasma and slowurinary excretion. Ceftriaxone is excreted in both the bileand the urine. Its urinary excretion is not affected byprobenecid. Despite its comparatively low volume ofdistribution, it reaches the cerebrospinal fluid in concentrationsthat are effective in meningitis. Nonlinear pharmacokineticsare observed.
Ceftriaxone contains a highly acidic heterocyclic systemon the 3-thiomethyl group. This unusual dioxotriazine ringsystem is believed to confer the unique pharmacokineticproperties of this agent. Ceftriaxone has been associatedwith sonographically detected “sludge,” or pseudolithiasis,in the gallbladder and common bile duct. Symptoms ofcholecystitis may occur in susceptible patients, especiallythose on prolonged or high-dose ceftriaxone therapy. Theculprit has been identified as the calcium chelate.
Ceftriaxone exhibits excellent broad-spectrum antibacterialactivity against both Gram-positive and Gram-negativeorganisms. It is highly resistant to most chromosomally andplasmid-mediated β-lactamases. The activity of ceftriaxoneagainst Enterobacter, Citrobacter, Serratia, indole-positiveProteus, and Pseudomonas spp. is particularly impressive. Itis also effective in the treatment of ampicillin-resistant gonorrheaand H. influenzae infections but generally less activethan cefotaxime against Gram-positive bacteria and B.fragilis.
Details
Product Description
Name |
Ceftriaxone Sodium |
EINECS | 277-930-0 |
CAS No. | 74578-69-1 | Density | N/A |
PSA | 296.63000 | LogP | -2.03600 |
Solubility | N/A | Melting Point | N/A |
Formula | C18H18N8Na2O7S3 | Boiling Point | N/A |
Molecular Weight | 598.552 | Flash Point | N/A |
Transport Information | N/A |
- proname: ceftriaxone sodium
- casno: 74578-69-1
- molecular formula: c18h18n8na2o7s3
- appearance: look at the detailed information
- application: intermediates
- deliverytime: according to the clients requirement
- package: according to the clients requirement
- port: china main port
- productioncapacity: 10 metric ton/year
- purity: 95%, 99%
- storage: according to the characteristics of th...
- transportation: by sea or air
- limitnum: 1 metric ton
Ceftriaxone sodium is a β-lactamase–resistantcephalosporin with an extremely long serum half-life.Once-daily dosing suffices for most indications. Two factorscontribute to the prolonged duration of action ofceftriaxone: high protein binding in the plasma and slowurinary excretion. Ceftriaxone is excreted in both the bileand the urine. Its urinary excretion is not affected byprobenecid. Despite its comparatively low volume ofdistribution, it reaches the cerebrospinal fluid in concentrationsthat are effective in meningitis. Nonlinear pharmacokineticsare observed.
Ceftriaxone contains a highly acidic heterocyclic systemon the 3-thiomethyl group. This unusual dioxotriazine ringsystem is believed to confer the unique pharmacokineticproperties of this agent. Ceftriaxone has been associatedwith sonographically detected “sludge,” or pseudolithiasis,in the gallbladder and common bile duct. Symptoms ofcholecystitis may occur in susceptible patients, especiallythose on prolonged or high-dose ceftriaxone therapy. Theculprit has been identified as the calcium chelate.
Ceftriaxone exhibits excellent broad-spectrum antibacterialactivity against both Gram-positive and Gram-negativeorganisms. It is highly resistant to most chromosomally andplasmid-mediated β-lactamases. The activity of ceftriaxoneagainst Enterobacter, Citrobacter, Serratia, indole-positiveProteus, and Pseudomonas spp. is particularly impressive. Itis also effective in the treatment of ampicillin-resistant gonorrheaand H. influenzae infections but generally less activethan cefotaxime against Gram-positive bacteria and B.fragilis.
Items |
Standard |
Result |
Appearance |
White to yellow-orange crystalline powder |
Off-white crystalline powder |
Identification |
Conforms |
Conforms |
Crystallinity |
Conforms |
Conforms |
PH |
6.0-8.0 |
7.4 |
Water |
8.0-11.0% |
9.4% |
Related substances |
Impurity A≤0.5% |
0.01% |
Impurity B.C≤0.5% |
0.01% |
|
Impurity D≤1.0% |
0.1% |
|
Impurity E≤0.2% |
Note detected |
|
Impurity F≤0.5% |
0.04% |
|
Impurity G≤0.5% |
0.03% |
|
Impurity H≤0.5% |
0.02% |
|
Any individual unspecified impurity ≤0.2% |
0.004% |
|
Total impurities ≤2.5% |
0.2% |
|
Bacterial endotoxins |
<0.20EU/mg |
<0.20EU/mg |
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