Tauroursodeoxycholic Acid CAS NO.14605-22-2

• ProName:High Quality 99% Tauroursodeoxycholic...
• CasNo:14605-22-2
• Molecular Formula:Refer to COA
• Appearance:powder
• Application:API, pharmaceutical excipients, nutrit...
• DeliveryTime:Shiping within 3 working days after co...
• PackAge:1kg/bag; 25kg/drum, or as customer's r...
• Port:Any main ports of China
• ProductionCapacity:100 Metric Ton/Year
• Purity:98%~102%
• Storage:Far from fire and heat, keep in cool p...
• Transportation:DHL, EMS, FedEx, TNT, AIR, SEA
• LimitNum:1 Gram
• Related Substances:≤0.1%
• Residue on Ignition:≤0.05%
• Heavy Metal:<10ppm
• Valid Period:24 months
• It can reduce the secretion of cholesterol by the liver, reduce the saturation of cholesterol in bile, promote the secretion of bile acid, increase the solubility of cholesterol in bile, dissolve cholesterol stones or prevent the formation of stones. It can increase bile secretion, relax the bile duct sphincter and produce choleretic effect, which is beneficial to the discharge of stones.

Product Name:TUDCA

CAS:14605-22-2

MF:C26H45NO6S

MW:499.7

Mol File: 14605-22-2.mol

Product Categories:Pharmaceuticals

Usage:Bear bile active ingredients, treatment of gallstones and liver disease

 

 

Tauroursodeoxycholic acid, more commonly referred to as TUDCA, is a bile salt that is found natrually occurring in the body. When regular bile salts reach the intestines, they can be metabolized by bacteria into UDCA and then later bound to a taurine molecule to become TUDCA.

 

TUDCA is a water-soluble bile salt, which is in contrast to regular bile salts possessing both water soluble and fat soluble ends and conferring a detergent effect. This is good for the bile salt's biological purpose (emulsifying fats in the intestines to help with absorption) but when bile acids back up in the liver, a clinical state called cholestasis which occurs when the liver is unhealthy, these bile salts can be damaging to cells by destroying the membranes and signalling for cell death. TUDCA and other water soluble bile salts like UDCA compete with this toxicity and thus indirectly protect cells from death.

 

Additionally, it seems that TUDCA is able to reduce stress to any cell's Endoplasmic Reticulum; an organelle in cells that serves as a highway from the nucleus out into the cytoplasm, and aids in folding proteins. Through reducing ER stress, TUDCA has been implicated in a wide range of beneficial metabolic effects such as reducing insulin resistance and diabetes, and being a neurological protection agent. However, usages of TUDCA beyond the liver are preliminary whereas usage of TUDCA for helping an already harmed liver is quite reliable as TUDCA is used in clinical settings (hospitals) for treating cholestasis.

 

 

Dosage:

10-13mg daily has once been shown to improve liver regenesis rates in a clinically ill population, and may be the lowest estimate of an active oral dose. When looking at improving bile salt composition, a dose around 15-20mg/kg bodyweight TUDCA seems best according to one study.

 

Benefits have been seen at 1,750mg daily for muscle and liver insulin sensitivity, which is the highest dose used for treatment of fatty liver disease.

 

Tauroursodeoxycholic Acid, also name Ursodeoxycholyltaurine (TUDCA), it is a liver aid introduced as a supplement by thermolife in their product liver longer. It appears to be a good resource for preventing cholestasis, one of the major risks with 17 alkylated steroids.

Tauroursodeoxycholic Acid is an ambiphilic bile acid. And it is the taurine conjugated form of ursodeoxycholic acid, which is used in the study. Humans are found to have trace amounts of TUDCA. However, bears contain large amounts of TUDCA in their bile.

Tauroursodeoxycholic Acid has diminishing apoptotic effects, it helping with cardiac function, huntington's disease, Parkinson's Disease and stroke.
Recently, TUDCA has been found to have protective effects in the eyes, especially concerning retinal degenerative diseases.

Quality Standard

Items	Specifications
Content (C26H45NO6S)	≥98%
Identification	Comparable HPLC chromatogram with the reference
Chloride	≤0.02%
Heavy metals	≤20ppm
Arsenate salt (as As)	≤2ppm
Loss on drying	≤2.0%
Appearance	White or almost white powder
Taste	Bitter, no smell

 

Function of TUDCA

TUDCA has significant protective properties for many organs throughout the human body. TUDCA protects skeletal muscles and other organs, particularly the liver, by increasing insulin sensitivity to appropriate levels. TUDCA has shown to do this by protecting the endoplasmic reticulum from stress.

Insulin resistance plays an important role in health issues related to excess fat. TUDCA has been used for many liver healing and immune-improving purposes, and also is used to support a healthy gallbladder.

This dietary supplement may have some powerful neuroprotective properties, and is indicated in the protection of cells from destruction.To protect cells, TUDCA regulate certain cell cycle effector genes. While these signaling pathways have been identified, the full role of TUDCA in cell maintenance is not yet fully understood.

By protecting cells from destruction, TUDCA has been proven to be effective in helping eye's maintain cones and rods.The photoreceptor protection is of great help in promoting healthy vision. TUDCA is also associated with increased antioxidant activity.

 

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