Valsartan CAS NO.137862-53-4

• ProName:99.9% up USP standard GMP certified DM...
• CasNo:137862-53-4
• Molecular Formula:C24H29N5O3
• Appearance:White or almost white hygroscopic powd...
• Application:Treat the hypertension
• DeliveryTime:7 working days
• PackAge:25kg per drum
• Port:shanghai/beijing/hangzhou
• ProductionCapacity:1000 Kilogram/Month
• Purity:99.9%
• Storage:Normal temperature
• Transportation:normal temperature.
• LimitNum:1 Kilogram

Product name:Valsartan 

Chemical name:3,5-Diiodo-4-PyridoneN-(1-Oxopentyl)-N-{[2'-(1H-tetrazol-5-yl

-1,1'-biphenyl)-4-yl]methyl}-L-valine
Molecular Formular:C24H29N5O3
Molecular Weight: 435.53
CAS NO.:137862-53-4

EINECS: N/A

 

Specifications:

Appearance: white powder,tasteless

Assay :99.0% 

Related substance:2.0% max 
Residue on ignition: 0.1% max 

Heavy metal:0.001% max

Loss on drying: 0.5% max 

Water: 2.0% max 

 

Packing: 25kg/cardboard drum  

Usage: used clinical for receptor antagonist of angiotensin AT1, 

has good effect to the different degree of hypertension patients

 who used other antihypertensive drugs without efficacy , is a new 

generation of highly efficient antihypertensive drugs

1. Basic informaiton for the valsartan

Product Name	Valsartan
Other name	N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine Diovan
Quality	USP36
Cas:	137862-53-4
Molecular Formula	C24H29N5O3
Molecular Weight	435.52

 

 

 

 

 

 

 

 

 

 

 

2. Function for the valsartan

Treat the hypertension

3. Specification for the valsartan

Items	Standard,	Results
Appearance	White or almost white hygroscopic powder	Almost white hygroscopic powder
solubility	Freely soluble in anhydrous ethanol, sparingly soluble in Methylene chloride, Practically insoluble in water	conforms
Absorbance	NMT 0.02 at 420nm (1/20 Methanol solution)	0.01
Identification	A: IR infared absorption spectrum is identical to that of valsartan reference standard B: The retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation, as obtained in the assay	Conforms         conforms
Water	NMT 2.0%	1.0%
Residue on ignition	NMT 0.1%	< 0.1%
Heavy metals	NMT 0.001%	< 0.001%
Related compounds
Related compound A	NMT 1.0%	0.31%
Related compound B	NMT 0.2%	0.02%
Related compound C	NMT 0.1%	N.D
Any other unspecified impurity	NMT 0.1%	0.03%
Total impurities ( not Include related compound A)	NMT 0.3%	0.17%
Assay	98.0-102% of C24H29N5O3,Calculated on the anhydrous basis	100.5%
Residual Solvents
Ethylacetate	NMT5000PPM	1249PPM
Methylenechloride	NMT 600PPM	N.D
toluene	NMT 890PPM	5PPM
Methanol	NMT 3000PPM	N.D
Dimethylformamide	NMT880PPM	N.D
Particle size	reference	D50: 40.56UM D90: 71.15UM
Bulk density	reference	0.31g/ml
Tapped density	reference	0.45g/ml
Conclusion	It conforms to USP36

 

 

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