• ProName:99% up GMP DMF Ceftriaxone Sodium 7457...
• CasNo:74578-69-1
• Molecular Formula:C18H18N8Na2O7S3
• Appearance:White or almost white hygroscopic powd...
• Application:API
• DeliveryTime:7 working days
• PackAge:25kg per drum
• Port:shanghai/beijing/hangzhou
• ProductionCapacity:1000 Kilogram/Month
• Purity:99%
• Storage:Normal temperature
• Transportation:normal temperature.
• LimitNum:1 Kilogram

• Ceftriaxone sodium is a β-lactamase–resistantcephalosporin with an extremely long serum half-life.Once-daily dosing suffices for most indications. Two factorscontribute to the prolonged duration of action ofceftriaxone: high protein binding in the plasma and slowurinary excretion. Ceftriaxone is excreted in both the bileand the urine. Its urinary excretion is not affected byprobenecid. Despite its comparatively low volume ofdistribution, it reaches the cerebrospinal fluid in concentrationsthat are effective in meningitis. Nonlinear pharmacokineticsare observed.
  Ceftriaxone contains a highly acidic heterocyclic systemon the 3-thiomethyl group. This unusual dioxotriazine ringsystem is believed to confer the unique pharmacokineticproperties of this agent. Ceftriaxone has been associatedwith sonographically detected “sludge,” or pseudolithiasis,in the gallbladder and common bile duct. Symptoms ofcholecystitis may occur in susceptible patients, especiallythose on prolonged or high-dose ceftriaxone therapy. Theculprit has been identified as the calcium chelate.
  Ceftriaxone exhibits excellent broad-spectrum antibacterialactivity against both Gram-positive and Gram-negativeorganisms. It is highly resistant to most chromosomally andplasmid-mediated β-lactamases. The activity of ceftriaxoneagainst Enterobacter, Citrobacter, Serratia, indole-positiveProteus, and Pseudomonas spp. is particularly impressive. Itis also effective in the treatment of ampicillin-resistant gonorrheaand H. influenzae infections but generally less activethan cefotaxime against Gram-positive bacteria and B.fragilis.

 

Product Description        

Name	Ceftriaxone Sodium	EINECS	277-930-0
CAS No.	74578-69-1	Density	N/A
PSA	296.63000	LogP	-2.03600
Solubility	N/A	Melting Point	N/A
Formula	C18H18N8Na2O7S3	Boiling Point	N/A
Molecular Weight	598.552	Flash Point	N/A
Transport Information	N/A

 

• proname: ceftriaxone sodium
• casno: 74578-69-1
• molecular formula: c18h18n8na2o7s3
• appearance: look at the detailed information
• application: intermediates
• deliverytime: according to the clients requirement
• package: according to the clients requirement
• port: china main port
• productioncapacity: 10 metric ton/year
• purity: 95%, 99%
• storage: according to the characteristics of th...
• transportation: by sea or air
• limitnum: 1 metric ton

  

Ceftriaxone sodium is a β-lactamase–resistantcephalosporin with an extremely long serum half-life.Once-daily dosing suffices for most indications. Two factorscontribute to the prolonged duration of action ofceftriaxone: high protein binding in the plasma and slowurinary excretion. Ceftriaxone is excreted in both the bileand the urine. Its urinary excretion is not affected byprobenecid. Despite its comparatively low volume ofdistribution, it reaches the cerebrospinal fluid in concentrationsthat are effective in meningitis. Nonlinear pharmacokineticsare observed.
Ceftriaxone contains a highly acidic heterocyclic systemon the 3-thiomethyl group. This unusual dioxotriazine ringsystem is believed to confer the unique pharmacokineticproperties of this agent. Ceftriaxone has been associatedwith sonographically detected “sludge,” or pseudolithiasis,in the gallbladder and common bile duct. Symptoms ofcholecystitis may occur in susceptible patients, especiallythose on prolonged or high-dose ceftriaxone therapy. Theculprit has been identified as the calcium chelate.
Ceftriaxone exhibits excellent broad-spectrum antibacterialactivity against both Gram-positive and Gram-negativeorganisms. It is highly resistant to most chromosomally andplasmid-mediated β-lactamases. The activity of ceftriaxoneagainst Enterobacter, Citrobacter, Serratia, indole-positiveProteus, and Pseudomonas spp. is particularly impressive. Itis also effective in the treatment of ampicillin-resistant gonorrheaand H. influenzae infections but generally less activethan cefotaxime against Gram-positive bacteria and B.fragilis.

Items	Standard	Result
Appearance	White to yellow-orange crystalline powder	Off-white crystalline powder
Identification	Conforms	Conforms
Crystallinity	Conforms	Conforms
PH	6.0-8.0	7.4
Water	8.0-11.0%	9.4%
Related substances	Impurity A≤0.5%	0.01%
	Impurity B.C≤0.5%	0.01%
	Impurity D≤1.0%	0.1%
	Impurity E≤0.2%	Note detected
	Impurity F≤0.5%	0.04%
	Impurity G≤0.5%	0.03%
	Impurity H≤0.5%	0.02%
	Any individual unspecified impurity ≤0.2%	0.004%
	Total impurities ≤2.5%	0.2%
Bacterial endotoxins	＜0.20EU/mg	＜0.20EU/mg

 

 

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